| Serum Modification | - |
| Region of origin | - |
| Volume | 100 ml |
Human AB Serum, or Human Serum Type AB, is obtained from human male AB plasma in FDA-licensed facilities in the USA. It is used as a supplement to cell culture media and for other cell culture assays. It could be described as blood plasma, where cells and clotting factors have been removed, and the proteins not used for clotting, antibodies, antigens, hormones, and electrolytes are preserved during the filtration process.
Human AB serum in a culture medium provides human cell lines with an environment that more closely resembles their physiological conditions than growth media supplemented with animal sera. This is of particular significance in micro-optical investigations of cell structures or differentiation studies, where results are intended to allow conclusions to be drawn regarding natural conditions in human tissue. Therefore, human sera may be superior to animal sera when culturing sensitive human cell lines, such as macrophages or lymphocytes.
Apart from being an additive for cell culture media, Human Serum Type AB is used for control assays, immunoassays, clinical chemistry, and in vitro diagnostics. Due to the nature of blood groups, it does not contain anti-A or anti-B antibodies, which can damage human cells in culture and disrupt immunological investigations.