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Anti-human phospho-181 tau-1E7 monoclonal antibody - 100 µg
Learn how to use this product Tau is a microtubule-associated protein comprised of six human isoforms predominantly located in the axons of neurons. Neuronal and/or glial inclusions of tau can be detected in several neurodegenerative diseases or “tauopathies”, including Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), Pick’s disease, and cortico-basal degeneration (CBD) and Creutzfeldt-Jakob disease (CJD) may be characterized by their tau isoform profiles.
Hyperphosphorylation of the neuronal tau protein is a hallmark of neurodegenerative tauopathies such as Alzheimer’s disease. New research suggests, that a few master phosphorylation sites - T50, T69, T111, T181, and T205 – trigger hyperphosphorylation of tau after they have been initially phosphorylated. (Stefanoska Ket al. Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation. Sci Adv. 2022 Jul 8;8(27):eabl8809. doi: 10.1126/sciadv.abl8809)
The antibody Anti-human phospho-181 TAU mab 1E7 specifically binds human TAU posphorylated at amino acid position 181 (T).
Purified, in PBS w/o additives, frozen at -20°C, 12 months shelf life. Applications: ELISA, WB, IHC, IF