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Phytohemagglutinin M (PHA-M) for Lymphocyte Stimulation is a mitogen that stimulates cell proliferation in lymphocyte cell cultures. It is a lectin extracted from red kidney beans (Phaseolus vulgaris). Phytohemagglutinin M consists of two molecular species, a leucoagglutinin (PHA-L) and an erythroagglutinin (PHA-E). Each protein contains a family of five isolectins, each being a tetramer held together by non-covalent forces. PHA-M is the mucoprotein form.

PHA-M was first used for the separation of leukocytes from whole blood. Its main application field is the stimulation of cell proliferation in lymphocyte cultures. It also has potent erythrocyte agglutinating properties.