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Anti-human TDP43 2G10 monoclonal antibody - 1 mg
Learn how to use this product The transactive response region DNA-binding protein 43 (TDP43) binds both DNA and RNA and is involved in transcription and splicing. Under pathophysiological conditions, TDP43 accumulates in the cytoplasm and is hyperphosphorylated and/ or ubiquitinated, and this is Characteristic of the cytoplasmic inclusions observed in ALS and in many cases of frontotemporal labor degeneration syndrome (FTLD). Furthermore, TDP43 pathology is also detected in 20-50 % of AD patients, and appears to be associated with greater brain atrophy, memory loss, and cognitive impairment.
The antibody Anti-human TDP43 mab 2G10 specifically binds to Amino acids 200-220 (MTEDELREFFSQYGDVM) of TDP43 protein.
Purified, in PBS w/o additives, frozen at -20°C, 12 months shelf life. Applications: ELISA, WB, IHC