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α-Synuclein is an abundant neuronal 140 amino acid protein, predominantly localized in the pre synaptic terminals, and involved in vesicle fusion and neurotransmitter release. Aggregates of α-synuclein are the main components of Lewy bodies (LB), which are intracellular inclusions characteristics of certain neurodegenerative diseases collectively referred to as α-synucleinopathies. These include Parkinson’s disease (PD), Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). However, α-synuclein aggregates are also found in approximately half of sporadic AD pathologies; consequently, it is crucial to differentiate it from pure AD forms.
The anti-human α-synuclein 5G4, monoclonal antibody binds to pathologically relevant structures in neuropathology of Lewy body/ Parkinson’s disease and is capable of recognizing β-sheet-dependent epitope.
Purified, in PBS w/o additives, frozen at -20°C, 12 months shelf life. Applications: ELISA, WB, IHC, IF
